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KMID : 0360220090500010139
Journal of the Korean Ophthalmological Society
2009 Volume.50 No. 1 p.139 ~ p.144
Analysis of Retinal Nerve Fiber Layer Thickness in Patients With Superior Segmental Optic Hypoplasia
Seo Jeong-Won

Park In-Won
Chung Yun-Suk
Abstract
Purpose: To analyze the thickness of the peripapillary retinal nerve fiber layer (RNFL) in patients with superior segmental optic hypoplasia (SSOH) using optical coherence tomography (OCT).

Methods: Ten eyes of 10 patients with SSOH and 20 eyes of 20 subjects as normal control were evaluated. The peripapillary RNFL thickness measured by Stratus OCT was compared between the two groups.

Results: The mean RNFL thickness was significantly different between SSOH patients (72.35¡¾14.77 ¥ìm) and normal subjects (111.61¡¾6.62 ¥ìm) (p<0.001). The extent to which the RNFL thickness was below 5 percentile of normal subjects on the TSNIT graph was from the 41.7¡¾15.53 to 110.1¡¾7.47 scan number, which corresponded mainly with the superior nasal region. Moreover, in a clock?hour analysis, the peripapillary RNFL thickness of the SSOH patients decreased significantly from 10 o\\\¡¯clock to 6 o\\\¡¯clock compared to normal subjects (p<0.01).

Conclusions: Peripapillary RNFL thickness in patients with SSOH was reduced in the superior, nasal, and inferior regions. Further studies involving larger populations of patients should be performed to verify these findings.
KEYWORD
Optical coherence tomography (OCT), RNFL thickness, Superior segmental optic hypoplasia (SSOH), Topless optic disc syndrome
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